Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD (
https://rheumatologytcd.com) is seeking to appoint three Post-Doctoral Fellow (2-3 years) to examine the underlying molecular mechanisms mediating immune-stromal cell interactions which are critically involved in driving inflammatory responses in Autoimmune Rheumatic Diseases.
Description of Projects: Inflammatory arthritis is a chronic autoimmune disease, the pathogenesis of which involves complex cellular interactions and networks of various cytokines that trigger the synovium to transform into a ‘tumor-like’ pannus, which invades both cartilage and bone, resulting in functional disability. In these project we will specifically focus on Immune-stromal cell interactions and examine (i) functional, metabolic and transcriptional regulation between immune and stromal cells and (ii) examine the potential of targeting newly identified pathways in novel co-culture models and in ex-vivo whole tissue synovial explant models. At a molecular single-cell level, we will be performing scRNAseq, VISIUM spatial-RNAseq, non-invasive imaging analysis, along with extensive mechanistic studies using 2D/3D scaffold culture models, which will dissect the distinct molecular signatures involved in driving differential immune cell pathogenic mechanisms in different pathotype and endotypes to identify (i) differential pathogenic mechanisms and (ii) identify new targets for novel therapeutic strategies. These project utilise a multidisciplinary approach combining expertise in molecular biology, metabolism, cell biology and bioengineering, applied to cell and tissue obtained from well-defined patient cohorts, in addition to examining the role for metabolic re-programming in the resolution of inflammation, thus will significantly contribute to our basic knowledge of the disease pathogenesis.
Applications are invited with experience in the areas of cell biology, immunology, biochemistry, molecular biology, physiology or a related discipline. Key techniques in this project include, primary cell culture, molecular biology, flow cytometry, ELISA/MSD assays, metabolic assays and imaging, organoid cultures Practical experience in some of these skills would be desirable.
Salary: The positions are on the post-doctoral IUA Salary Scale, of PD1 level- point 3-6; €54,936-€59,771 (salary inclusive of pension/PRSI) or PD2 level-point 1-4; €61,470-€66,881 (salary inclusive of pension/PRSI) depending on experience
Informal enquiries to Prof Ursula Fearon,
[email protected] Molecular Rheumatology, TCD (
https://rheumatologytcd.com).
How to Apply: The candidate should apply directly to
[email protected] along with a detailed CV and cover note.
