Postdoctoral Scientist
Salary £39,375 per annum pro rata
MRC Laboratory of Molecular Biology, Cambridge, UK
The position is for two Postdoctoral Scientists with expertise on cryoEM and/or protein biochemistry. You will be responsible for expressing, purifying phosphatases and kinases and solving their structures using a combination of approaches primarily cryoEM and/or crystallography (with the support of LMB facilities). You may also develop new inhibitors and conduct functional studies.
Dr Anne Bertolotti’s pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al,. Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024). The small molecules discovered by the lab are currently tested in clinical trials for neurodegenerative diseases. You will provide fundamental structural and mechanistic insights on these important enzymes and expand on the next generation of inhibitors.
You will join a strong inter-disciplinary team at the LMB, which has broad expertise extending from biochemistry, structural, chemical, molecular and cell biology through to transgenic animal models of degenerative diseases. The team also has an excellent record of innovative basic research leading to applications in medicine.
Further information about the position may be obtained from Dr Anne Bertolotti via email:
[email protected] You will be ambitious, creative and fearless, able to invent new approaches to explore the unknown. You will have a PhD in biochemistry or structural biology or due to complete doctoral studies within 6 months of applying. Relevant experience is required, and this must be best attested by at least one impactful and original publication. Interests in signaling enzymes is desirable.
You will enjoy interacting with a dynamic interdisciplinary team sharing a passion for science and a commitment to explore the unknown.
This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.
The LMB has an inclusive and collaborative working culture, and you will be based in our state-of-the-art building on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. You will be able to access our range of excellent benefits including a staff restaurant with roof terrace, on-site nursery, sports and social facilities. You will be eligible to join our defined benefit pension scheme with an employer contribution of 16%, holiday entitlement of 40.5 days per annum (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications.
The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at
www.ukri.org and
www.mrc-lmb.cam.ac.uk.
This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).
To apply and access full details of the vacancy please visit our job board at
https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/2782 If you are unable to apply online, please contact us at
[email protected].
Closing date: 13/11/2024
We actively support equality, diversity and inclusion in all our activities, processes and culture.
We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require;
[email protected].
