Applications are invited for a temporary post of a Post-doctoral Research Fellow Level 1 within UCD School of Biomolecular and Biomedical Science.
The Chromatin Architecture in Cancer laboratory (
https://conwaychromatinlab.com/) at University College Dublin, led by Dr. Eric Conway, are recruiting a postdoctoral fellow to work on targeting the super-enhancer network in acute myeloid leukemia. This position will be funded through a Wellcome Trust award.
Project description
Acute myeloid leukemia (AML) has one of the worst prognoses of haematological cancers. It frequently results in post-treatment relapse due to its complex clonal heterogeneity allowing for the expansion of minimal residual disease populations. Therefore, targeting epigenomic pathways common across genetically diverse clones, rather than the dominant clonal genotype, is an avenue that demands exploration. Transcription factor (TF) pathways are imminently druggable due to an expanding library of epigenetic inhibitor compounds, however in order to effectively implement this approach, there must first be a molecular understanding of patient-specific transcriptional circuits.
This project will define the mechanism-of-action of the AML core TFs in controlling transcription and the epigenome in order to identify a means to target AML. Using a combination of in vitro and primary patient samples, this project has established model systems to investigate these mechanisms in depth. This will primarily involve functional genomics assays (ChIP-seq, RNA-seq, CUT&Tag, Hi-C) and single-cell epigenomics data analysis to define the core regulatory circuitry of individual patients, or distinct intra-patient leukemic clones. This inter-disciplinary project will involve close collaboration with clinical haematologists at St. James’s hospital, wet-lab & computational biologists at UCD and international research groups. The role of the applicant will be a computational biology position to lead the analysis of epigenomic data, currently being generated, to uncover novel molecular sensitivities of AML patients/clones with distinct genotypes.
Salary Range: €44,847 - €51,313 per annum
Appointment on the above range will be dependent upon qualifications and experience.
Closing date: 12:00 noon (local Irish time) on 30th of April 2025.
Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 12:00 noon (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.
UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.
The PD1 position is intended for early stage researchers, either just after completion of a PhD or for someone entering a new area for the first time. If you have already completed your PD1 stage in UCD or will soon complete a PD1, or you are an external applicant whose total Postdoctoral experience, inclusive of the duration of the advertised post, would exceed 4 years, you should not apply and should refer to PD2 posts instead.
Prior to application, further information (including application procedure) should be obtained from the Work at UCD website:
https://www.ucd.ie/workatucd/jobs/
