The Genome Stability and Innate Immunity Team, led by Dr Christian Zierhut, seeks to understand how innate immune responses are activated during genotoxic stress, and to establish how these regulate cell fate. Ultimately, we aim to develop rule sets for how cell fate can be manipulated during cancer therapy. We employ a multi-disciplinary approach that combines state of the art cell biology, genetic screening, biochemistry and structural biology techniques. More information can be found at
https://www.zierhutlab.org/.
Our team is embedded within the Cancer Biology Division at the ICR’s Chester Beatty Laboratories in Chelsea, London. We have a highly supportive and interactive research environment, and state of the art facilities for cell biology, molecular biology, next-generation sequencing and structural biology. The great variety of disciplines at the ICR will ensure that you will be exposed to fantastic research and seminars from all types of backgrounds.
We seek two postdoctoral research scientists to develop exciting research programmes to analyse innate immune signalling during genotoxic stress. The first of these projects will use quantitative imaging approaches to establish a detailed understanding of how innate immune signalling is established, and how it mediates its effects. The second project will reveal innate immune effectors of the response to genotoxic stress through genomic analysis and genetic screens, followed by genetic and biochemical analysis. In both projects, the successful candidate will have intellectual freedom in developing this project together with the Team Leader, whilst working as part of a collaborative and multi-disciplinary team.
Applicants should hold a PhD in molecular biology/cell biology/biochemistry or similar, and have an extensive background in genome instability and/or cell cycle control and/or innate immunity, or at least in some of these. A strong background in first-author publications, as well as experience in quantitative imaging or the analysis of genomic data are desirable.
Candidates are also expected to have experience in basic molecular biology techniques (recombinant DNA, sub-cloning, Western blots etc.) and in cell biology techniques of mammalian cells (tissue culture, transfection methods, microscopy). Basic experience with CRISPR is desirable.
This position is offered on a fixed term contract for 3 years to start with. The salary is £38,607 per annum (£32,844 is a starting salary for pre-viva new starters until the PhD award).Future progression is based on annual performance review.
To apply please submit an online application including the supporting statement (addressing with specific examples where you meet the person specification, a brief description of your relevant experience and incl. the names and addresses of at least two referees). You will need to upload your CV as part of the application process.
For more information please refer to the job description. Job ref 1247
